Possible Sites of Therapeutic Action in Restless Legs Syndrome: Focus on Dopamine and α₂δ Ligands

Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and α2δ ligands.

Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by abnormal sensations that occur primarily at rest or during sleep, which are alleviated by movement of the affected limb. The pathophysiology of RLS remains unclear, although roles for dopamine dysfunction and brain iron deficiency have been proposed. The hypothalamic A11 dopaminergic circuit is used to explain the d...

Peripheral Dopamine in Restless Legs Syndrome

Objective/Background Restless Legs Syndrome (RLS) is a dopamine-dependent disorder characterized by a strong urge to move. The objective of this study was to evalulate blood levels of dopamine and other catecholamines and blood D2-subtype dopamine receptors (D2Rs) in RLS. Patients/Methods Dopamine levels in blood samples from age-matched unmedicated RLS subjects, medicated RLS subjects and Co...

Dopamine agonists for restless legs syndrome.

BACKGROUND According to clinical guidelines, dopamine agonists are the first-line treatment of restless legs syndrome (RLS). OBJECTIVES To evaluate efficacy and safety of dopamine agonists for RLS. SEARCH STRATEGY We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library 2008, Issue 4), MEDLINE, EMBASE, PsycINFO and CINAHL, from January 1985 to December 2008, plus...

Restless Legs Syndrome Prevalence in Major Thalasemia Tabriz Children Hospital

Dopamine agonists for the treatment of restless legs syndrome.

The restless legs syndrome is a neurological disorder characterised by the urge to move the extremities associated with paraesthesias, which are partially or totally relieved by movement, a worsening of symptoms at rest and in the evening or at night and, as a consequence, sleep disturbances. Restless legs syndrome is common and affects 1-10% of the population. The aetiology of restless legs sy...